Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

Acute myeloid leukemia (AML) can display de novo or acquired resistance to cytosine arabinoside (Ara-C), a primary component of induction chemotherapy. To identify genes capable of independently imposing Ara-C resistance, we applied a genome-wide CRISPR library to human U937 cells and exposed to the...

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Detalles Bibliográficos
Autores principales: Kurata, Morito, Rathe, Susan K., Bailey, Natashay J., Aumann, Natalie K., Jones, Justine M., Veldhuijzen, G. Willemijn, Moriarity, Branden S., Largaespada, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093682/
https://www.ncbi.nlm.nih.gov/pubmed/27808171
http://dx.doi.org/10.1038/srep36199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093682/
https://www.ncbi.nlm.nih.gov/pubmed/27808171
http://dx.doi.org/10.1038/srep36199

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