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Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly

The binding of metal ions at the interface of protein complexes presents a unique and poorly understood mechanism of molecular assembly. A remarkable example is the Rad50 zinc hook domain, which is highly conserved and facilitates the Zn(2+)-mediated homodimerization of Rad50 proteins. Here, we pres...

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Detalles Bibliográficos
Autores principales: Kochańczyk, Tomasz, Nowakowski, Michał, Wojewska, Dominika, Kocyła, Anna, Ejchart, Andrzej, Koźmiński, Wiktor, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093744/
https://www.ncbi.nlm.nih.gov/pubmed/27808280
http://dx.doi.org/10.1038/srep36346