α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

α-Synuclein (αS) is a protein linked to Parkinson’s disease (PD) and related neurodegenerative disorders. It is mostly localized within synapses, but αS has also been suggested to play a role in the nucleus. We used transgenic Drosophila and inducible SH-SY5Y neuroblastoma cells to investigate the e...

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Detalles Bibliográficos
Autores principales: Sugeno, Naoto, Jäckel, Sandra, Voigt, Aaron, Wassouf, Zinah, Schulze-Hentrich, Julia, Kahle, Philipp J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093762/
https://www.ncbi.nlm.nih.gov/pubmed/27808254
http://dx.doi.org/10.1038/srep36328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093762/
https://www.ncbi.nlm.nih.gov/pubmed/27808254
http://dx.doi.org/10.1038/srep36328

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