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Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties

Calreticulin (CRT) is a multifaceted protein, initially discovered as an endoplasmic reticulum (ER) chaperone protein, that is essential in calcium metabolism. Various implications in cancer, early development and immunology have been discovered more recently for CRT, as well as its role as a domina...

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Detalles Bibliográficos
Autores principales: Moreau, Christophe, Cioci, Gianluca, Iannello, Marina, Laffly, Emmanuelle, Chouquet, Anne, Ferreira, Arturo, Thielens, Nicole M., Gaboriaud, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094443/
https://www.ncbi.nlm.nih.gov/pubmed/27840680
http://dx.doi.org/10.1107/S2052252516012847