Reduction of metal adducts in oligonucleotide mass spectra in ion‐pair reversed‐phase chromatography/mass spectrometry analysis

RATIONALE: Electrospray ionization mass spectrometry (ESI‐MS)‐based techniques commonly used in oligonucleotide analyses are known to be sensitive to alkali metal adduct formation. Adducts directly impact the sensitivity of MS‐based analyses as the available charge is distributed across the parent p...

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Detalles Bibliográficos
Autores principales: Birdsall, Robert E., Gilar, Martin, Shion, Henry, Yu, Ying Qing, Chen, Weibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094505/
https://www.ncbi.nlm.nih.gov/pubmed/28328039
http://dx.doi.org/10.1002/rcm.7596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094505/
https://www.ncbi.nlm.nih.gov/pubmed/28328039
http://dx.doi.org/10.1002/rcm.7596

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