Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses

It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, and mass spectrometry (MS). Here MS, th...

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Detalles Bibliográficos
Autores principales: Yee, Ai Woon, Moulin, Martine, Breteau, Nina, Haertlein, Michael, Mitchell, Edward P., Cooper, Jonathan B., Boeri Erba, Elisabetta, Forsyth, V. Trevor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094506/
https://www.ncbi.nlm.nih.gov/pubmed/27311939
http://dx.doi.org/10.1002/anie.201602747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094506/
https://www.ncbi.nlm.nih.gov/pubmed/27311939
http://dx.doi.org/10.1002/anie.201602747

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