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Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation
Recent evidence indicates that inhibition of protein translation may be a common pathogenic mechanism for peripheral neuropathy associated with mutant tRNA synthetases (aaRSs). aaRSs are enzymes that ligate amino acids to their cognate tRNA, thus catalyzing the first step of translation. Dominant mu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094542/ https://www.ncbi.nlm.nih.gov/pubmed/27352040 http://dx.doi.org/10.1002/bies.201600052 |