Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics

Alzheimer′s disease has recently emerged as a possible field of application for PDE4D inhibitors (PDE4DIs). The great structure similarity among the various PDE4 isoforms and, furthermore, the lack of the full length crystal structure of the enzyme, impaired the rational design of new selective PDE4...

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Detalles Bibliográficos
Autores principales: D'Ursi, Pasqualina, Guariento, Sara, Trombetti, Gabriele, Orro, Alessandro, Cichero, Elena, Milanesi, Luciano, Fossa, Paola, Bruno, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094559/
https://www.ncbi.nlm.nih.gov/pubmed/27546041
http://dx.doi.org/10.1002/minf.201501033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094559/
https://www.ncbi.nlm.nih.gov/pubmed/27546041
http://dx.doi.org/10.1002/minf.201501033

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