Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are strongly associated with familial Parkinson’s disease (PD). High expression levels in immune cells suggest a role of LRRK2 in regulating the immune system. In this study, we investigated the effect of the LRRK2 (G2019S) mutation in monocytes, usi...

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Detalles Bibliográficos
Autores principales: Speidel, Anna, Felk, Sandra, Reinhardt, Peter, Sterneckert, Jared, Gillardon, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094768/
https://www.ncbi.nlm.nih.gov/pubmed/27812199
http://dx.doi.org/10.1371/journal.pone.0165949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094768/
https://www.ncbi.nlm.nih.gov/pubmed/27812199
http://dx.doi.org/10.1371/journal.pone.0165949

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