Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells

The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation of the kinase PERK and the resultant phosphorylation of eIF2’s alpha subunit (e...

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Detalles Bibliográficos
Autores principales: Sekine, Yusuke, Zyryanova, Alisa, Crespillo-Casado, Ana, Amin-Wetzel, Niko, Harding, Heather P., Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094784/
https://www.ncbi.nlm.nih.gov/pubmed/27812215
http://dx.doi.org/10.1371/journal.pone.0166278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094784/
https://www.ncbi.nlm.nih.gov/pubmed/27812215
http://dx.doi.org/10.1371/journal.pone.0166278

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