Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are resistant to conventional cytotoxic drugs, inhibition of autophagy represents a promising therapeutic strategy in clinical oncology. We previously...

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Detalles Bibliográficos
Autores principales: Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Autophagy and Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094956/
https://www.ncbi.nlm.nih.gov/pubmed/27248168
http://dx.doi.org/10.18632/oncotarget.9601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094956/
https://www.ncbi.nlm.nih.gov/pubmed/27248168
http://dx.doi.org/10.18632/oncotarget.9601

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