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FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation
Mutations that deregulate protein degradation lead to human malignancies. The SCF ubiquitin E3 ligase complex degrades key oncogenic regulators, thereby limiting their oncogenic potential. FBW7 is a substrate recognition subunit of SCF(FBW7) and is among the most commonly mutated ubiquitin-proteasom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094957/ https://www.ncbi.nlm.nih.gov/pubmed/27232758 http://dx.doi.org/10.18632/oncotarget.9595 |