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FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation

Mutations that deregulate protein degradation lead to human malignancies. The SCF ubiquitin E3 ligase complex degrades key oncogenic regulators, thereby limiting their oncogenic potential. FBW7 is a substrate recognition subunit of SCF(FBW7) and is among the most commonly mutated ubiquitin-proteasom...

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Detalles Bibliográficos
Autores principales:	Wang, Jingming, Jo, Ukhyun, Joo, So Young, Kim, Hyungjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Chromosome
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094957/ https://www.ncbi.nlm.nih.gov/pubmed/27232758 http://dx.doi.org/10.18632/oncotarget.9595

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