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Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma

The molecular mechanisms whereby transforming growth factor-β (TGF-β) promotes clear cell renal cell carcinoma (ccRCC) progression is elusive. The cell membrane bound TGF-β type I receptor (ALK5), was recently found to undergo proteolytic cleavage in aggressive prostate cancer cells, resulting in li...

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Detalles Bibliográficos
Autores principales: Sitaram, Raviprakash T., Mallikarjuna, Pramod, Landström, Maréne, Ljungberg, Börje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094972/
https://www.ncbi.nlm.nih.gov/pubmed/27166254
http://dx.doi.org/10.18632/oncotarget.9177