The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 overexpression has been reported in many types of cancer and associated with poor prognosis. Here we investigated the expression and functionality of EZH2 in chronic lymphocy...

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Detalles Bibliográficos
Autores principales: Papakonstantinou, Nikos, Ntoufa, Stavroula, Chartomatsidou, Elisavet, Kotta, Konstantia, Agathangelidis, Andreas, Giassafaki, Lefki, Karamanli, Tzeni, Bele, Panagiota, Moysiadis, Theodoros, Baliakas, Panagiotis, Sutton, Lesley Ann, Stavroyianni, Niki, Anagnostopoulos, Achilles, Makris, Antonios M., Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094974/
https://www.ncbi.nlm.nih.gov/pubmed/27191993
http://dx.doi.org/10.18632/oncotarget.9371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094974/
https://www.ncbi.nlm.nih.gov/pubmed/27191993
http://dx.doi.org/10.18632/oncotarget.9371

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