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The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 overexpression has been reported in many types of cancer and associated with poor prognosis. Here we investigated the expression and functionality of EZH2 in chronic lymphocy...
Autores principales: | Papakonstantinou, Nikos, Ntoufa, Stavroula, Chartomatsidou, Elisavet, Kotta, Konstantia, Agathangelidis, Andreas, Giassafaki, Lefki, Karamanli, Tzeni, Bele, Panagiota, Moysiadis, Theodoros, Baliakas, Panagiotis, Sutton, Lesley Ann, Stavroyianni, Niki, Anagnostopoulos, Achilles, Makris, Antonios M., Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094974/ https://www.ncbi.nlm.nih.gov/pubmed/27191993 http://dx.doi.org/10.18632/oncotarget.9371 |
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