CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway

Cyclin-dependent kinase 5 (CDK5) has been documented in podocyte injuries in diabetic nephropathy (DN), however its role in renal tubular epithelial cells has not been elucidated. We report here that CDK5 is detrimental and promotes tubulointerstitial fibrosis (TIF) via the extracellular signal-regu...

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Detalles Bibliográficos
Autores principales: Bai, Xiaoyan, Hou, Xiaoyan, Tian, Jianwei, Geng, Jian, Li, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095017/
https://www.ncbi.nlm.nih.gov/pubmed/27145370
http://dx.doi.org/10.18632/oncotarget.9058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095017/
https://www.ncbi.nlm.nih.gov/pubmed/27145370
http://dx.doi.org/10.18632/oncotarget.9058

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