The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation

We characterized the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway, leading to cell cycle arrest and apoptosis in vitro and regression of pancreatic and breast cancer in vivo. We found that 9F7-F11 induces rapid HER3 dow...

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Detalles Bibliográficos
Autores principales: Le Clorennec, Christophe, Lazrek, Yassamine, Dubreuil, Olivier, Larbouret, Christel, Poul, Marie-Alix, Mondon, Philippe, Melino, Gerry, Pèlegrin, André, Chardès, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095055/
https://www.ncbi.nlm.nih.gov/pubmed/27203743
http://dx.doi.org/10.18632/oncotarget.9455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095055/
https://www.ncbi.nlm.nih.gov/pubmed/27203743
http://dx.doi.org/10.18632/oncotarget.9455

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