The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic membranes and essential for structural integrity and signaling function of cell membranes required for cancer cell growth. Inhibition of choline kinase alpha (CHKA), the first committed step to phosph...

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Detalles Bibliográficos
Autores principales: Trousil, Sebastian, Kaliszczak, Maciej, Schug, Zachary, Nguyen, Quang-De, Tomasi, Giampaolo, Favicchio, Rosy, Brickute, Diana, Fortt, Robin, Twyman, Frazer J., Carroll, Laurence, Kalusa, Andrew, Navaratnam, Naveenan, Adejumo, Thomas, Carling, David, Gottlieb, Eyal, Aboagye, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095062/
https://www.ncbi.nlm.nih.gov/pubmed/27206796
http://dx.doi.org/10.18632/oncotarget.9466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095062/
https://www.ncbi.nlm.nih.gov/pubmed/27206796
http://dx.doi.org/10.18632/oncotarget.9466

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