Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the rapid and progressive degeneration of upper and lower motor neurons in the spinal cord, brain stem and motor cortex. The first gene linked to ALS was the gene encoding the free radical scavenging enzyme sup...

Descripción completa

Detalles Bibliográficos
Autores principales: McAlary, Luke, Aquilina, J. Andrew, Yerbury, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095133/
https://www.ncbi.nlm.nih.gov/pubmed/27867347
http://dx.doi.org/10.3389/fnins.2016.00499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095133/
https://www.ncbi.nlm.nih.gov/pubmed/27867347
http://dx.doi.org/10.3389/fnins.2016.00499

Ejemplares similares