Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cystein...

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Detalles Bibliográficos
Autores principales: Bernardim, Barbara, Cal, Pedro M.S.D., Matos, Maria J., Oliveira, Bruno L., Martínez-Sáez, Nuria, Albuquerque, Inês S., Perkins, Elizabeth, Corzana, Francisco, Burtoloso, Antonio C.B., Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095172/
https://www.ncbi.nlm.nih.gov/pubmed/27782215
http://dx.doi.org/10.1038/ncomms13128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095172/
https://www.ncbi.nlm.nih.gov/pubmed/27782215
http://dx.doi.org/10.1038/ncomms13128

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