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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cystein...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095172/ https://www.ncbi.nlm.nih.gov/pubmed/27782215 http://dx.doi.org/10.1038/ncomms13128 |