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Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane

The human YME1L protease is a membrane-anchored AAA+ enzyme that controls proteostasis at the inner membrane and intermembrane space of mitochondria. Understanding how YME1L recognizes substrates and catalyses ATP-dependent degradation has been hampered by the presence of an insoluble transmembrane...

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Detalles Bibliográficos
Autores principales:	Shi, Hui, Rampello, Anthony J., Glynn, Steven E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095350/ https://www.ncbi.nlm.nih.gov/pubmed/27786171 http://dx.doi.org/10.1038/ncomms13301

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