Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer

When injected directly into a tumor mass, adenovirus (Ad) vectors only transduce cells immediately along the injection tract. Expression of fusogenic proteins from the Ad vector can lead to syncytium formation, which efficiently spreads the therapeutic effect. Fusogenic proteins can also cause cance...

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Detalles Bibliográficos
Autores principales: Wong, C M, Nash, L A, Del Papa, J, Poulin, K L, Falls, T, Bell, J C, Parks, R J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095592/
https://www.ncbi.nlm.nih.gov/pubmed/27740615
http://dx.doi.org/10.1038/cgt.2016.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095592/
https://www.ncbi.nlm.nih.gov/pubmed/27740615
http://dx.doi.org/10.1038/cgt.2016.41

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