Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex

Caspase-8 is a key initiator of apoptotic cell death where it functions as the apical protease in death receptor-mediated apoptosis triggered via the death-inducing signalling complex (DISC). However, the observation that caspase-8 is upregulated in many common tumour types led to the discovery of a...

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Detalles Bibliográficos
Autores principales: Powley, I R, Hughes, M A, Cain, K, MacFarlane, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095593/
https://www.ncbi.nlm.nih.gov/pubmed/27109099
http://dx.doi.org/10.1038/onc.2016.99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095593/
https://www.ncbi.nlm.nih.gov/pubmed/27109099
http://dx.doi.org/10.1038/onc.2016.99

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