A simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics

Anti-mitotic drugs constitute a major class of cytotoxic chemotherapeutics used in the clinic, killing cancer cells by inducing prolonged mitotic arrest that activates intrinsic apoptosis. Anti-mitotics-induced apoptosis is known to involve degradation of anti-apoptotic Bcl-2 proteins during mitotic...

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Detalles Bibliográficos
Autores principales: Kueh, Hao Yuan, Zhu, Yanting, Shi, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095668/
https://www.ncbi.nlm.nih.gov/pubmed/27811996
http://dx.doi.org/10.1038/srep36585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095668/
https://www.ncbi.nlm.nih.gov/pubmed/27811996
http://dx.doi.org/10.1038/srep36585

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