A Cytochrome P450‐Mediated Intramolecular Carbon–Carbon Ring Closure in the Biosynthesis of Multidrug‐Resistance‐Reversing Lathyrane Diterpenoids

The Euphorbiaceae produce a wide variety of bioactive diterpenoids. These include the lathyranes, which have received much interest due to their ability to inhibit the ABC transporters responsible for the loss of efficacy of many chemotherapy drugs. The lathyranes are also intermediates in the biosy...

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Detalles Bibliográficos
Autores principales: King, Andrew J., Brown, Geoffrey D., Gilday, Alison D., Forestier, Edith, Larson, Tony R., Graham, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095812/
https://www.ncbi.nlm.nih.gov/pubmed/27272333
http://dx.doi.org/10.1002/cbic.201600316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095812/
https://www.ncbi.nlm.nih.gov/pubmed/27272333
http://dx.doi.org/10.1002/cbic.201600316

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