Fragment‐Based Drug Design Facilitated by Protein‐Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

There is an urgent need for the development of efficient methodologies that accelerate drug discovery. We demonstrate that the strategic combination of fragment linking/optimization and protein‐templated click chemistry is an efficient and powerful method that accelerates the hit‐identification proc...

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Detalles Bibliográficos
Autores principales: Mondal, Milon, Unver, M. Yagiz, Pal, Asish, Bakker, Matthijs, Berrier, Stephan P., Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095814/
https://www.ncbi.nlm.nih.gov/pubmed/27604032
http://dx.doi.org/10.1002/chem.201603001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095814/
https://www.ncbi.nlm.nih.gov/pubmed/27604032
http://dx.doi.org/10.1002/chem.201603001

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