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Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity

A novel chemical platform based on branched piperazine‐2,5‐dione derivatives (2,5‐diketopiperazines) for creating orally available biologically active peptidomimetics has been developed. The platform includes a diketopiperazine scaffold with “built‐in” functionally active peptide fragments covalentl...

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Detalles Bibliográficos
Autores principales: Deigin, Vladislav, Ksenofontova, Olga, Khrushchev, Alexey, Yatskin, Oleg, Goryacheva, Alexandra, Ivanov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095862/
https://www.ncbi.nlm.nih.gov/pubmed/27457274
http://dx.doi.org/10.1002/cmdc.201600157