A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One‐Step Cleavage of the Dabcyl Quencher

Sirtuins (SIRTs) are a family of NAD(+)‐dependent histone deacetylases. In mammals, dysfunction of SIRTs is associated with age‐related metabolic diseases and cancers, so SIRT modulators are considered attractive therapeutic targets. However, current screening methodologies are problematic, and no t...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Mitsuyasu, Ikegawa, Shohei, Ieda, Naoya, Nakagawa, Hidehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095863/
https://www.ncbi.nlm.nih.gov/pubmed/27542094
http://dx.doi.org/10.1002/cbic.201600374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095863/
https://www.ncbi.nlm.nih.gov/pubmed/27542094
http://dx.doi.org/10.1002/cbic.201600374

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