Synthesis and Biological Evaluation of Iodoglucoazomycin (I‐GAZ), an Azomycin–Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors

Iodoglucoazomycin (I‐GAZ; N‐(2‐iodo‐3‐(6‐O‐glucosyl)propyl)‐2‐nitroimidazole), a non‐glycosidic nitroimidazole–6‐O‐glucose adduct, was synthesized, radioiodinated, and evaluated as a substrate of glucose transporter 1 (GLUT1) for radiotheranostic (therapy+diagnostic) management of hypoxic tumors. Nu...

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Detalles Bibliográficos
Autores principales: Kumar, Piyush, Elsaidi, Hassan R. H., Zorniak, Bohdarianna, Laurens, Evelyn, Yang, Jennifer, Bacchu, Veena, Wang, Monica, Wiebe, Leonard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095876/
https://www.ncbi.nlm.nih.gov/pubmed/27377671
http://dx.doi.org/10.1002/cmdc.201600213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095876/
https://www.ncbi.nlm.nih.gov/pubmed/27377671
http://dx.doi.org/10.1002/cmdc.201600213

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