Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence

Mammalian glutamate dehydrogenase (GDH), a nuclear-encoded enzyme central to cellular metabolism, is among the most abundant mitochondrial proteins (constituting up to 10% of matrix proteins). To attain such high levels, GDH depends on very efficient mitochondrial targeting that, for human isoenzyme...

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Detalles Bibliográficos
Autores principales: Kalef-Ezra, Ester, Kotzamani, Dimitra, Zaganas, Ioannis, Katrakili, Nitsa, Plaitakis, Andreas, Tokatlidis, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095901/
https://www.ncbi.nlm.nih.gov/pubmed/27422783
http://dx.doi.org/10.1042/BCJ20160535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095901/
https://www.ncbi.nlm.nih.gov/pubmed/27422783
http://dx.doi.org/10.1042/BCJ20160535

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