Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding

BACKGROUND: Human lactoferrin is an iron-binding protein of the innate immune system consisting of two connected lobes, each with a binding site located in a cleft. The clefts in each lobe undergo a hinge movement from open to close when Fe(3+) is present in the solution and can be bound. The bindin...

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Detalles Bibliográficos
Autores principales: Sill, Clemens, Biehl, Ralf, Hoffmann, Bernd, Radulescu, Aurel, Appavou, Marie-Sousai, Farago, Bela, Merkel, Rudolf, Richter, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095980/
https://www.ncbi.nlm.nih.gov/pubmed/27822363
http://dx.doi.org/10.1186/s13628-016-0032-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095980/
https://www.ncbi.nlm.nih.gov/pubmed/27822363
http://dx.doi.org/10.1186/s13628-016-0032-3

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