More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances

Rosuvastatin is a substrate of choice in clinical studies of organic anion‐transporting polypeptide (OATP)1B1‐ and OATP1B3‐associated drug interactions; thus, understanding the effect of OATP1B1 polymorphisms on the pharmacokinetics of rosuvastatin is crucial. Here, physiologically based pharmacokin...

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Detalles Bibliográficos
Autores principales: Emami Riedmaier, Ariane, Burt, Howard, Abduljalil, Khaled, Neuhoff, Sibylle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096019/
https://www.ncbi.nlm.nih.gov/pubmed/27385171
http://dx.doi.org/10.1002/jcph.669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096019/
https://www.ncbi.nlm.nih.gov/pubmed/27385171
http://dx.doi.org/10.1002/jcph.669

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