Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin‐Targeting Thiazole Analogue of Bisebromoamide

Systematic alanine scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, was enabled by solid‐phase peptide synthesis of thiazole analogues. The analogues have comparable cytotoxicity (nanomolar) to that of BBA, and cellular morphology assays indicated that they...

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Detalles Bibliográficos
Autores principales: Johnston, Heather J., Boys, Sarah K., Makda, Ashraff, Carragher, Neil O., Hulme, Alison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096027/
https://www.ncbi.nlm.nih.gov/pubmed/27304907
http://dx.doi.org/10.1002/cbic.201600257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096027/
https://www.ncbi.nlm.nih.gov/pubmed/27304907
http://dx.doi.org/10.1002/cbic.201600257

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