Cargando…

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin‐Targeting Thiazole Analogue of Bisebromoamide

Systematic alanine scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, was enabled by solid‐phase peptide synthesis of thiazole analogues. The analogues have comparable cytotoxicity (nanomolar) to that of BBA, and cellular morphology assays indicated that they...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnston, Heather J., Boys, Sarah K., Makda, Ashraff, Carragher, Neil O., Hulme, Alison N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096027/ https://www.ncbi.nlm.nih.gov/pubmed/27304907 http://dx.doi.org/10.1002/cbic.201600257

Ejemplares similares

Halogen-containing thiazole orange analogues – new fluorogenic DNA stains
por: Vasilev, Aleksey A, et al.
Publicado: (2017)

Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells
por: Suzuki, Kenjiro, et al.
Publicado: (2013)

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes
por: Miskinyte, Migla, et al.
Publicado: (2022)

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways
por: Warchal, Scott J., et al.
Publicado: (2020)

High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery
por: Hughes, Rebecca E., et al.
Publicado: (2020)

Linking Genetics to Structural Biology: Complex Heterozygosity Screening with Actin Alanine Scan Alleles Identifies Functionally Related Surfaces on Yeast Actin
por: DiPrima, Stephanie, et al.
Publicado: (2014)

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2018)

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients
por: Marwick, John A., et al.
Publicado: (2021)

(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues
por: de Meijere, Armin, et al.
Publicado: (2014)

Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2020)

Thiazole formation through a modified Gewald reaction
por: Mallia, Carl J, et al.
Publicado: (2015)

Selective and Efficient Generation of ortho-Brominated para-Substituted Phenols in ACS-Grade Methanol
por: Georgiev, David, et al.
Publicado: (2016)

A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging
por: Fernandez, Antonio, et al.
Publicado: (2022)

Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease
por: Singh, Shivani, et al.
Publicado: (2021)

Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase
por: Dindo, Mirco, et al.
Publicado: (2022)

Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2
por: Migoń, Dorian, et al.
Publicado: (2018)

Synthesis and Ab Initio/DFT Studies on 2-(4-methoxyphenyl)benzo[d]thiazole
por: Arslan, Hakan, et al.
Publicado: (2007)

Thiazole-induced rigidification in substituted dithieno-tetrathiafulvalene: the effect of planarisation on charge transport properties
por: Taylor, Rupert G D, et al.
Publicado: (2015)

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex
por: Anand, Praveen, et al.
Publicado: (2014)

New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues
por: Zhao, Alan X., et al.
Publicado: (2021)

A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection
por: Wolfram, Stefanie, et al.
Publicado: (2014)

Wood‐Inspired Cement with High Strength and Multifunctionality
por: Wang, Faheng, et al.
Publicado: (2020)

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes
por: Hughes, Rebecca E., et al.
Publicado: (2022)

The dynamic distribution of fluorescent analogues of actin and myosin in protrusions at the leading edge of migrating Swiss 3T3 fibroblasts
Publicado: (1988)

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach
por: Oueis, Emilia, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of New (−)‐Englerin Analogues
por: López‐Suárez, Laura, et al.
Publicado: (2016)

Incorporation of β‐Alanine in Cu(II) ATCUN Peptide Complexes Increases ROS Levels, DNA Cleavage and Antiproliferative Activity
por: Heinrich, Julian, et al.
Publicado: (2021)

Structural and Functional Characterization of a Multifunctional Alanine-Rich Peptide Analogue from Pleuronectes americanus
por: Migliolo, Ludovico, et al.
Publicado: (2012)

Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition of 5H-thiazol-4-ones with N-itaconimides
por: Qiu, Shuai, et al.
Publicado: (2016)

DFT study on some polythiophenes containing benzo[d]thiazole and benzo[d]oxazole: structure and band gap
por: Vu Quoc, Trung, et al.
Publicado: (2021)

Inspired by Nature—Functional Analogues of Molybdenum and Tungsten-Dependent Oxidoreductases
por: Pätsch, Sebastian, et al.
Publicado: (2022)

Synthesis, Characterization and Metal Ion Detection of Novel Fluoroionophores Based on Heterocyclic Substituted Alanines
por: Costa, Susana P. G., et al.
Publicado: (2007)

Synthesis of 2,3-dihydronaphtho[2,3-d][1,3]thiazole-4,9-diones and 2,3-dihydroanthra[2,3-d][1,3]thiazole-4,11-diones and novel ring contraction and fusion reaction of 3H-spiro[1,3-thiazole-2,1'-cyclohexanes] into 2,3,4,5-tetrahydro-1H-carbazole-6,11-diones
por: Konstantinova, Lidia S, et al.
Publicado: (2013)

Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents
por: Elmorsy, Mohamed R., et al.
Publicado: (2022)

Investigation of the active site of an unclassified glutathione transferase in Bombyx mori by alanine scanning
por: Yamamoto, Kohji, et al.
Publicado: (2020)

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library
por: Welford, Amanda J, et al.
Publicado: (2016)

Computational Intelligence‐Assisted Understanding of Nature‐Inspired Superhydrophobic Behavior
por: Zhang, Xia, et al.
Publicado: (2017)

An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes
por: Liu, Mohan, et al.
Publicado: (2021)

Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues
por: Schneider, Christopher M., et al.
Publicado: (2016)

N,O‐Nucleoside Analogues: Metabolic and Apoptotic Activity
por: Marraffa, Andrea, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ovmh8525vp58lnl5414jmnbht4