Laboratory‐Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme‐Catalyzed Epoxide Hydrolysis

Engineered enzyme variants of potato epoxide hydrolase (StEH1) display varying degrees of enrichment of (2R)‐3‐phenylpropane‐1,2‐diol from racemic benzyloxirane. Curiously, the observed increase in the enantiomeric excess of the (R)‐diol is not only a consequence of changes in enantioselectivity for...

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Detalles Bibliográficos
Autores principales: Janfalk Carlsson, Åsa, Bauer, Paul, Dobritzsch, Doreen, Nilsson, Mikael, Kamerlin, S. C. Lynn, Widersten, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096066/
https://www.ncbi.nlm.nih.gov/pubmed/27383542
http://dx.doi.org/10.1002/cbic.201600330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096066/
https://www.ncbi.nlm.nih.gov/pubmed/27383542
http://dx.doi.org/10.1002/cbic.201600330

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