Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

Adaptive resistance of myeloma to proteasome inhibition represents a clinical challenge, whose biology is poorly understood. Proteasome mutations were implicated as underlying mechanism, while an alternative hypothesis based on low activation status of the unfolded protein response was recently sugg...

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Detalles Bibliográficos
Autores principales: Soriano, G P, Besse, L, Li, N, Kraus, M, Besse, A, Meeuwenoord, N, Bader, J, Everts, B, den Dulk, H, Overkleeft, H S, Florea, B I, Driessen, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097071/
https://www.ncbi.nlm.nih.gov/pubmed/27118406
http://dx.doi.org/10.1038/leu.2016.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097071/
https://www.ncbi.nlm.nih.gov/pubmed/27118406
http://dx.doi.org/10.1038/leu.2016.102

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