Engineering and optimising deaminase fusions for genome editing

Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could intr...

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Detalles Bibliográficos
Autores principales: Yang, Luhan, Briggs, Adrian W., Chew, Wei Leong, Mali, Prashant, Guell, Marc, Aach, John, Goodman, Daniel Bryan, Cox, David, Kan, Yinan, Lesha, Emal, Soundararajan, Venkataramanan, Zhang, Feng, Church, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097136/
https://www.ncbi.nlm.nih.gov/pubmed/27804970
http://dx.doi.org/10.1038/ncomms13330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097136/
https://www.ncbi.nlm.nih.gov/pubmed/27804970
http://dx.doi.org/10.1038/ncomms13330

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