Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Chemical strategies to using small molecules to stimulate hypoxia inducible factors (HIFs) activity and trigger a hypoxic response under normoxic conditions, such as iron chelators and inhibitors of prolyl hydroxylase domain (PHD) enzymes, have broad-spectrum activities and off-target effects. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097156/
https://www.ncbi.nlm.nih.gov/pubmed/27811928
http://dx.doi.org/10.1038/ncomms13312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097156/
https://www.ncbi.nlm.nih.gov/pubmed/27811928
http://dx.doi.org/10.1038/ncomms13312

Ejemplares similares