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Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology

There is considerable debate whether Alzheimer's disease (AD) originates in basal forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal forebrain and entorhinal cortex grey matter volume were interdependent and sequential. In a large cohort of age-matched olde...

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Detalles Bibliográficos
Autores principales: Schmitz, Taylor W., Nathan Spreng, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097157/
https://www.ncbi.nlm.nih.gov/pubmed/27811848
http://dx.doi.org/10.1038/ncomms13249