Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage

BACKGROUND: NH exchangers (NHEs) play a crucial role in regulating intra/extracellular pH, which is altered in cancer cells, and are therefore suitable targets to alter cancer cell metabolism in order to inhibit cell survival and proliferation. Among NHE inhibitors, amiloride family members are comm...

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Detalles Bibliográficos
Autores principales: Aredia, Francesca, Czaplinski, Sebastian, Fulda, Simone, Scovassi, A. Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097842/
https://www.ncbi.nlm.nih.gov/pubmed/27816051
http://dx.doi.org/10.1186/s12885-016-2878-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097842/
https://www.ncbi.nlm.nih.gov/pubmed/27816051
http://dx.doi.org/10.1186/s12885-016-2878-9

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