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Acute alloxan toxicity causes granulomatous tubulointerstitial nephritis with severe mineralization

Alloxan had been recognized as having a direct nephrotoxic effect different from its diabetogenic action. We encountered previously unreported granulomatous tubulointerstitial nephritis with severe luminal and interstitial mineralization in one diabetic rat after one week of alloxan administration....

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Detalles Bibliográficos
Autores principales: Zhang, Lianshan, Terayama, Yui, Nishimoto, Taiki, Kodama, Yasushi, Ozaki, Kiyokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097969/
https://www.ncbi.nlm.nih.gov/pubmed/27821911
http://dx.doi.org/10.1293/tox.2016-0017