SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4()

Succinate dehydrogenase (SDH) is a heterotetrameric complex, among which the catalytic core SDHB loss-of-function mutations lead to mitochondrial enzyme SDH dysfunction and are associated with cancer formation. However, the impact of SDHB loss on colorectal carcinoma and the underlying mechanisms ar...

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Detalles Bibliográficos
Autores principales: Wang, Haiyu, Chen, Yusheng, Wu, Guohao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097976/
https://www.ncbi.nlm.nih.gov/pubmed/27816688
http://dx.doi.org/10.1016/j.tranon.2016.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097976/
https://www.ncbi.nlm.nih.gov/pubmed/27816688
http://dx.doi.org/10.1016/j.tranon.2016.09.009

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