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Proteome-wide Structural Analysis of PTM Hotspots Reveals Regulatory Elements Predicted to Impact Biological Function and Disease

Post-translational modifications (PTMs) regulate protein behavior through modulation of protein-protein interactions, enzymatic activity, and protein stability essential in the translation of genotype to phenotype in eukaryotes. Currently, less than 4% of all eukaryotic PTMs are reported to have bio...

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Detalles Bibliográficos
Autores principales: Torres, Matthew P., Dewhurst, Henry, Sundararaman, Niveda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098047/
https://www.ncbi.nlm.nih.gov/pubmed/27697855
http://dx.doi.org/10.1074/mcp.M116.062331