Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity

Background. Preclinical data indicate that trabectedin followed by irinotecan has strong synergistic effects on Ewing sarcoma. This is presumably due to hypersensitization of the tumor cells to the camptothecin as an effect of trabectedin in addition to synergistic suppression of EWS-FLI1 downstream...

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Detalles Bibliográficos
Autores principales: Herzog, J., von Klot-Heydenfeldt, F., Jabar, S., Ranft, A., Rossig, C., Dirksen, U., Van den Brande, J., D'Incalci, M., von Luettichau, I., Grohar, P. J., Berdel, W. E., Burdach, St.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098094/
https://www.ncbi.nlm.nih.gov/pubmed/27843394
http://dx.doi.org/10.1155/2016/7461783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098094/
https://www.ncbi.nlm.nih.gov/pubmed/27843394
http://dx.doi.org/10.1155/2016/7461783

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