Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical bi...

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Detalles Bibliográficos
Autores principales: Wong, Jocelyn P., Todd, Jason R., Finetti, Martina A., McCarthy, Frank, Broncel, Malgorzata, Vyse, Simon, Luczynski, Maciej T., Crosier, Stephen, Ryall, Karen A., Holmes, Kate, Payne, Leo S., Daley, Frances, Wai, Patty, Jenks, Andrew, Tanos, Barbara, Tan, Aik-Choon, Natrajan, Rachael C., Williamson, Daniel, Huang, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098123/
https://www.ncbi.nlm.nih.gov/pubmed/27783942
http://dx.doi.org/10.1016/j.celrep.2016.10.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098123/
https://www.ncbi.nlm.nih.gov/pubmed/27783942
http://dx.doi.org/10.1016/j.celrep.2016.10.005

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