Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth

Toll-like receptor 4 (TLR4) activation by bacterial infection, or by sterile inflammatory insult is a primary trigger of spontaneous preterm birth. Here we utilize mouse models to investigate the efficacy of a novel small molecule TLR4 antagonist, (+)-naloxone, the non-opioid isomer of the opioid re...

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Detalles Bibliográficos
Autores principales: Chin, Peck Yin, Dorian, Camilla L., Hutchinson, Mark R., Olson, David M., Rice, Kenner C., Moldenhauer, Lachlan M., Robertson, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098167/
https://www.ncbi.nlm.nih.gov/pubmed/27819333
http://dx.doi.org/10.1038/srep36112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098167/
https://www.ncbi.nlm.nih.gov/pubmed/27819333
http://dx.doi.org/10.1038/srep36112

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