Anti-tumor activity of SL4 against breast cancer cells: induction of G(2)/M arrest through modulation of the MAPK-dependent p21 signaling pathway

SL4, a chalcone-based compound, has been shown to retard tumor invasion and angiogenesis by suppressing HIF1 activity and to induce apoptosis by promoting ROS release. Here, we report that SL4 is able to inhibit the proliferation of different types of breast cancer cell in vitro and in vivo by induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Li-Hui, Jiang, Xiao-Rui, Chen, Guo-Liang, Guo, Wei, Zhang, Jing-Yuan, Cui, Li-Juan, Li, Hua-Huan, Li, Meng, Liu, Xing, Yang, Jing-Yu, Wu, Chun-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098232/
https://www.ncbi.nlm.nih.gov/pubmed/27819344
http://dx.doi.org/10.1038/srep36486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098232/
https://www.ncbi.nlm.nih.gov/pubmed/27819344
http://dx.doi.org/10.1038/srep36486

Ejemplares similares