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Understanding rare and common diseases in the context of human evolution
The wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection affect the purge of rare, deleterious mutations from the human population, whereas positive and balancing selection can increase the frequency of a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098287/ https://www.ncbi.nlm.nih.gov/pubmed/27821149 http://dx.doi.org/10.1186/s13059-016-1093-y |